Cardiff Labour candidate Stephen Doughty triumphed in the polls and Labour candidate Lucy Powell won the Manchester Central by-election, making her the first female MP for her party in the area.
As the Conservatives fear a hammering at the polls, the newly elected female MP took a swipe at the coalition government, saying that voters had sent a 'clear message' to the Conservative and Liberal Democrats.
Voters at Manchester Central Ward's by-election picked Labour Candidate Lucy Powell
She easily trounced her rivals at the polls, receiving 11,507 votes to Liberal Democrat's 1,571 and Conservative's 754.
As she made her victory speech, she said that voters clearly believed that the Government's policies are 'wrong and unfair.'
She went on to reiterate Ed Miliband's 'One Nation' message, saying that the country deserved to be united and does not have a 'divide of the rich against the poor, the North and South and the public against the private.'
Ms Powell accused the Government of being responsible for the 'break up of vital services and institutions' that the people of her ward depended upon.
In a blow for the Prime Minister, protest voters were expected to flock to the UK Independence Party on what was already being dubbed ‘Black Friday’.
The defeats are expected to embolden Mr Cameron’s own rebellious backbenchers.